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BioMicroDevices


BioMicroDevices Team

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Group leader

Thérèse LEBLOIS

Context

Our BioMicroDevices team was created in March 2015 during a reorganization of the MN2S Department’s research areas. The objective, in this highly multidisciplinary theme, is to develop devices and instrumentation systems for analyses of biological entities.


Goals and Research Areas

The team’s goal is to develop microdevices enabling measurement of biological targets (high-sensitivity detection, quantification, characterization) in a liquid environment for applications in the domains of health, the environment and the food industry.

The challenges targeted are those of sensitivity, specificity and multiplexing. They are addressed via acoustic or optic methods, biofunctionalization strategies differentiated from multimaterials composing microsystems, and engineering for the miniaturization of zones of analysis.


Expertise

The strength of the BioMicroDevices team is in its expertise in all the different areas, from the design, modeling and fabrication of devices, to testing them in real conditions (i.e. quasi-physiological, as soon as biological interactions come into play), in close cooperation with final users.

To meet these goals, the team relies on a set of multidisciplinary skills: micro- and nanofabrication technologies, multiscale and multiparameter characterization, MEMS, biochemistry, biophysics and instrumentation.

The team can also count on two technological and instrumental platforms, the platform MIMENTO of the Renatech network and the proteomics platform CLIPP (CLinical and Innovation Proteomic Platform) of the UBFC.


Implementing our work

The team’s developments fall within the research area of LABEX ACTION, particularly in WP4 (microsystems, technologies, components, integration).

The investigations undertaken within the last five years (2010-2015) have had an international scientific and technological impact in the following domains:
› analyses of biomolecular interactions without marking;
› multiplexed biochips for in vitro diagnosis and screening;
› analytical platforms for characterization of biological targets in clinical research;
› acoustic-wave microsensors;
› acoustic microactuators for activation and the mixing of fluids or particles in fluids;
› distributed MEMS;
› micro-/nanostructuration and characterization of devices based on active materials.