BIND

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Context

The research activities developed within the BIND (BioInterfaces aNd Devices) team are guided by the application domain, which ranges from surface bio-engineering to fluidic bio-microdevices.

In this context, BIND researchers are interested in the design of microdevices for the bio-detection and quantification of specific biological elements in “lab-on-chip” or “organ-on-chip” devices. These high-performance microdevices combine actuators, biosensors and bioengineering for active control and multi-scale characterization of complex biofluids.

objectives and scientific THEMES

In the BIND team, we are developing microdevices for the detection, sorting, qualification and quantification of biological elements in a complex environment using two parallel and complementary approaches:

• Bottom-up approach which consists in developing, from an existing biointerface, a high-performance microdevice (high sensitivity, low limit detection, fast response) allowing detection, sorting and quantification of specific analytes.
• Top-down approach which consists in developing, on an existing microdevice, a specific 2D or 3D biointerface. The originality of the 3D structure of bioengineering relates to its multiscale properties (nano, micro and macro) from a physical, chemical and structural point of view.

Expertise

The strong point of the BIND team lies in the mastery of all the skills necessary for the design, modeling and manufacture of devices up to their tests in real conditions (i.e. quasi-physiological when they bring into play biological interactions) in close collaboration with end users. The team thus offers know-how ranging from the choice of material and its structuring, the mode of transduction, the engineering of various prokaryotic and eukaryotic biological elements, the optimization of the bio-recognition surface to the final result of bio-detection and assay.

This know-how is based on the scientific specialties of the team members:

Microfluidics, microfabrication, acoustic and optical sensors and actuators, cellular and tissue bioengineering, physic and chemistry of surfaces and interfaces, multiphysics simulation, antibacterial and biocompatible surfaces.

Thus, the keywords describing the BIND research team can be divided into 5 points:

• Elaboration & characterization/control of biointerfaces
• Design of biosensors and microfluidic devices
• Development of lab-on-chip/organ-on-chip integrating sensors/actuators
• Multi-scale & multi-target qualification in flow and complex fluids
• Cell and tissue engineering/antibacterial protection

Implementing our work

Applications :

•  In health: understanding of biological mechanisms (diagnostic aim) and development of personalized drugs (therapeutic aim).
• In the food industry: rapid detection and very low concentration limit of pathogens/pollutants in complex fluids, and control of manufacturing processes.
• In the environment: detection of specific elements such as polluants or pathogens