MN2S department
Phononics and microscopies, acoustics, micro and nanotechnologies

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In a context of developing research at the nanoworld scale, the Nano2BIO team brings together skills in the fields of analysis, biodetection and multiphysical and multiscale characterisation. It develops tools and methodologies for multiplex label-free characterisation of biological targets, in the service of biology and health.

Objectives and research areas

The team addresses scientific issues such as biosensing and metrological, morphomechanical and spectral nanocaracterisation of biological objects of interest, and proposes multimodal bioanalytical and methodological solutions. To this end, it develops biofunctionalization strategies for organic and inorganic substrates to propose functional interfaces based on synthetic and natural ligands. It aims to detect biological targets (molecular, vesicular and cellular) or synthetic compounds under non-ideal conditions. Conversely, Nano2BIO is also interested in measuring molecular interactions under ideal conditions, and in studying the correlation between the measured signal and trapped molecules, between the measured signal and the number/shape/size of trapped objects. Nano2BIO aims to provide a multi-scale and multi-omics qualification of a sample to contribute to a better understanding of "composition and function" relationships.


  • Development of micro/nanostructured substrates & grafting strategies for synthetic and natural ligands
  • Determination of kinetic and molecular interaction constants in heterogeneous phase
  • Biodetection of biological targets of interest - molecular, vesicular and cellular - by surface plasmon resonance and Raman interferometry and spectroscopy
  • Echemometric analysis of multimodal data, for fine discrimination of coexisting subpopulations of interest in a sample

implementing our work

The work undertaken by the team has led to scientific, technological and methodological recognition on a national and international scale in the following fields

  • analyses of biomolecular interactions without labelling ;
  • multiplex biochips for in vitro diagnosis and screening
  • analytical platforms and methodologies for the characterisation (phenotypic, metrological, morphomechanical and spectral) of biological targets of interest in complex media;
  • Raman spectroscopy on nano-objects trapped on biochips, to allow discriminating analysis of sub-populations of interest.
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