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The challenges of food safety, diagnosis and therapeutic monitoring improvement, personalized medicine require a combination of multidisciplinary expertise at the frontier of engineering and life sciences. Based on this observation, the Biomicrodevices team was created in 2015, bringing together specialists from these two scientific fields in order to address these 21st century challenges.
Goals and Research Areas
The team’s goal is to develop bio-interfaces and microdevices for measurement of biological targets with specificity and high metrological performance, and to carry out multiscale and multi-target characterization in complex liquid media. The targeted applications are within the fields of health, environment and agri-food.
The main challenges for microdevices are sensitivity, specificity and multiplexing. They are addressed via acoustic or optical transduction methods and differentiated bio-functionalization strategies depending on materials used. The team works in close collaboration with health actors for a better understanding of biological phenomena.
The strength of the BioMicroDevices team is in the control of the overall process from the design, modeling and manufacturing of the devices until tests under real conditions (i.e. quasi-physiological conditions when tests involve biological interactions) in close collaboration with the end users. Our team can thus propose/offer the choice of material and its structuring, the transduction mode, the optimization of the bio-recognition surface to the final result of bio-detection and dosage.
To achieve these objectives, the group relies on a set of multidisciplinary skills: advanced instrumentation, microfabrication, microfluidics, acousto-fluidic interaction, biomedical optics, multiscale characterization of biofluids, synthesis of specific bio-interfaces.
The team also relies on two technological and instrumental platforms, the MIMENTO platform of the Renatech national network of microfabrication, and the CLIPP proteomics platform of the UBFC.
Thanks to strong links with hospitals and the Clinical Investigation Center (CIC), the team is strongly involved in translational research.
Implementing our work
The developments carried out by the team are in line with the axes defined by the EUR EIPHI, in particular in the axis 2 "Self-adaptive architectures".
The work carried out by our team has led to international scientific and technological recognition in the following areas:
- label-free analyses of biomolecular interactions
- multiplex biochips for in vitro diagnosis and screening,
- analytical platforms for the characterization of biological targets in physiological environments,
- micro acoustic wave sensors in a microfluidic environment,
- optical spectroscopy
- acoustic micro-actuators for particle separation and sorting in fluids.