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PhD
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PhD : Microrobotic for cell sorting

Context : The micro mechatronic (AS2M) department of the FEMTO-ST Institute aims to develop lab on chip for highly selective cell sorting based on robotic approaches. Its goal is to propose the next generation of automated cell sorters in the framework of immunotherapy. Immunotherapy is a highly innovating technique based on optimizing the immune response of the patients. Impressive results have been obtained on people suffering from cancers. This highly personalized technique consists in isolating the rare lymphocytes of the patient presenting anti-tumor activity, duplicating them by cell culture, and administering the cloned lymphocytes to the patient. However, in most cases, this treatment must face a major challenge: the identification of these rare natural lymphocytes having a concentration lower than 0.1%, which is beyond the detection level of current techniques

Objective of the thesis :
The objective of this work is to improve the selectivity of the current cell sorters by developing the next generation of lab on chip based on robotics

Contact: 

Contact : aude.bolopion@femto-st.fr

+ d'infos :
PDF icon ThesisEN_Microrobotic_AS2M

PhD thesis : Development of a silicon micro-device dedicated to the selective detection of VOCs in indoor air

Context : The quality of the indoor air within buildings is a topic of major importance for public health. Among the numerous chemical compounds that can be found in indoor air, formaldehyde and BTEX (benzene, toluene, ethylbenzene and xylene) are considered as one of the most toxic volatile organic compounds (VOCs).

Objectif : In this context, the goal of this study is to develop and deeply characterize an in-situ micro-device able to identify and quantify these chemical compounds in indoor air. A silicon micro-preconcentrator, a silicon gas chromatographic micro-column and a semiconductor based chemiresistor gas sensor will compose this analytical micro-system.
The main contributions in this thesis concern on one hand the identification and characterization of suitable porous adsorbents allowing the concentration of indoor air pollutants and, on the other hand the synthesis of nano-structured metal oxides (SnO2) using an original deposition technique.
The aim of this PhD is to synthesize and characterize various materials (adsorbents and metal oxide materials) and then to evaluate the detection performances of the micro-device for the identification of indoor air pollutants such as formaldehyde and VOCs.

Candidates’profile : Skills in physical-chemistry, surface science, instrumentation, physical properties of nanostructures, semiconductors and structural characterization techniques.

Calendar :
Subject to be filled before the end of June 2018
Taking office from October 2018

Contact: 

Supervisor : Jean-Baptiste Sanchez
jbsanche@univ-fcomte.fr, +33 (0)3 63 08 24 93

Co-supervisor : Franck Berger

+ d'infos :
PDF icon offre_these_femto_st_minamas_2018.pdf

PhD : Design, modeling, fabrication and characterization of a Stirling micro - engine for energy harvesting and conversion

Context : This project concerns the development of a micro-Stirling enginen for energy harvesting (recovery of lost thermal energy and conversion into electrical energy, and vice versa). It is a collaborative project between the departments MN2S (MOEMSgroup) and ENERGY(THERMIEteam) of theINSTITUT FEMTO-ST–Département MN2S15 B avenue des Montboucons 25030 BESANCON cedex www.femto-st.fr FEMTO-ST institute and which is the result of a committed work with academic partners (University of Savoie and University of Sherbrooke-Canada) on the development of a miniaturized Stirling engine for energy recovery. 

Objective : This phD thesis aims at the realization of a miniaturized Stirling engine by means of clean room technologies (available within the Femto-st institute). In the context of previous projects, some elements of the micro-Stirling engine have already been developed (hybrid membranes, micro-regenerators) [6-9]. 

Contact: 

Michel DE LABACHELERIE - labachel@femto-st.fr ;

Magali BARTHES - magali.barthes@femto-st.fr ;

Sylvie BEGOT - sylvie.begot@univ-fcomte.fr

 

+ d'infos :
PDF icon sujet_en_sirling.pdf

Ph.D : Specification and Verification in the Field of Quantum programs

Scientific context : The theory of quantum programming is increasingly studied since the beginning of the 21st century.
Several quantum programming languages have been proposed. Various aspects of quantum computing have been modelized in Haskell, Coq or Isabelle.
This work is in relation with I-QUINS, an I-SITE-BFC project (contract ANR-15-IDEX-03), which brings together theoretical and practical researchers in the field of quantum computing, working together on the building and miniaturization of physical quantum systems.

Candidates Profile and Application : The candidates should have a master degree in computer science, with proved skills in the general area of formal methods, formal specification, verification and validation. Skills in Coq or Isabelle proof environments will be appreciated. Proficiency in English is important, and the candidates shall master writing and presenting scientific work.

 

Contact: 

Alain Giorgetti

Pierre-Alain Masson

Frédéric Holveck

+ d'infos :
PDF icon phdofferfemto-st_ed-spim-quantumalgos18.pdf

Ph.D: Nanotribology of Triboactive Surfaces – Molecularly-assisted Tuning of Friction Laws in a Multi-asperity Tribocontact

Topic: The design and control of materials at the nanoscale are the foundation of many new strategies for energy generation, storage and efficiency. Friction is an important limitation of energy efficiency performances in MEMS/NEMS, whereas it is the primary mean to create energy in new Triboelectric NanoGenerators – ie. nanodevice used for energy harvesting. In this framework, multi-asperity nanotribology studies are needed to develop a fundamental understanding of interfacial phenomena where frictional behavior is controlled by interactions between nano-asperities. The goal of this PhD thesis is to develop new kinds of triboactive surfaces – ie, surfaces in which frictional behavior can be controlled in situ by means of external stimuli – more specifically focused on UV-beam photo-actived monolayers.

Background: Master degree or equivalent degree in physical-chemistry, surface science, or nanophysics

Period: Autumn 2018 – Autumn 2021

Contact: 

Supervisor: Dr. Philippe Stempflé (PhD-HDR), FEMTO-ST - ENSMM

email: philippe.stempfle@ens2m.fr

tél: +33 (0)3 63 08 24 96

+ d'infos :
PDF icon More informations concerning this thesis