The post-doctoral work addresses the development of a miniaturized biosensor for the monitoring and detection of potential bacterial cell contamination in medicinal products. Specificity, sensitivity and rapid response are the three points to focus on in the proposed work. First step will be dedicated to design, including multiphysics simulation (waves properties in a complex liquid environment) of the device. Second step will concern fabrication (including clean room processes), strategies for miniaturization and experimental validation. The device will be tested in several conditions with biologists to validate its efficiency in the qualification of new medicinal products.
The objective of the post-doctoral project is the compliance of a miniaturized biosensor for off-line qualification of biological fluids. At medium-term, this device is developed for being integrated in the biodrug production line and/or in a lab-on-chip for an on-line biodetection of dedicated species.
The candidate will benefit from the skills and experience of our laboratory in the field of microtechnology, acoustic devices, microfluidic, instrumentation, nanocharacterization, biochemistry and will operate in the clean-room facilities of FEMTO-ST.
She/he will be involved in the design (FEM simulations), microfabrication of prototypes including the fluidic cell with acoustic transducer and in the experimental setup to control the microfluidic devices.
The candidate should be qualified in applied physics or engineering sciences and with a strong interest for interdisciplinary environment and experiments. He/she should possess skills among MEMS, biosensors, acoustics, instrumentation and multiphysics simulation. Some knowledge on biomedical aspects will be appreciated.